According to the recent study clearing out the old cells from your joints can stop and can even reverse the development of Osteoarthritis. The people leading a sedentary lifestyle are more prone to Osteoarthritis.
Osteoarthritis is a type of joint disease that causes pain and stiffness in joints. The experts recommend an active and healthy lifestyle to people to lower down the risk of disease. Now, the researchers have come up with an alternate solution that will wipe out the old cells from our body to reverse the aging process. The removal of old cells from our body can make one feel more rejuvenated. The same technique of removing the old cells from the joints can cut down the risk of developing osteoarthritis among the potential individuals.
Old Cells or Senescent Cells
Senescent cells cause due to biological aging is characterized by a gradual reduction in the functioning of cells. This cell aging reduces the stamina of internal organs during old age. Many studies have proved that removal of these senescent cells can improve the functioning of different organs and improve the life expectancy.
The Conducted Study
The study was individually conducted on old and young mice to evaluate the effectiveness of the study. The researchers first cut the young mice to trace their anterior cruciate ligaments (ACL) to resemble with that of humans. After 14 days when the joints of mice started showing the symptoms of degradation the researchers injected these mice with UBX0101. UBX0101 is a drug that is known to wipe out the senescent cells. In both the categories of mice, the old cells were removed by 50% which was enough to stop the development of osteoarthritis.
In young mice, the genes linked to cartilage repair were triggered immediately after injections that quickly repaired the joints and removed old cells. In old mice, the cartilage layer was thin and have caused intense pain and have not shown any regeneration. The study has been published in the journal Nature Medicine on April 24.